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Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Engineering doi: 10.1016/j.eng.2023.02.016

Abstract: To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effectiveThrough the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbuminMoreover, this approach “visualizes” N-glycans that have been difficult to identify thus far—such asthe sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary gel    

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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: The structure of N-glycans on specific proteins can regulate innate and adaptive immunity viaglycan structural interpretation tool StrucGP in N-glycoproteomic analysis.spectrometry (MS)-based glycoproteomic approaches, followed by the large-scale mapping of site-specific glycanstructures via StrucGP.The findings indicated that these structures may be closely related to macrophage polarization.

Keywords： macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

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Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis Article

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Engineering 2023, Volume 26, Issue 7,   Pages 151-158 doi: 10.1016/j.eng.2023.03.008

Abstract: Serum N-glycan profiles were tested using DNA sequencer-assisted fluorophore-assisted carbohydrateA total of nine N-glycan peaks were identified in serum samples for each subject.The diagnostic value of the constructed N-glycan models and other fibrotic markers was evaluatedIn distinguishing significant liver fibrosis, the diagnostic efficiency of the serum N-glycanIn distinguishing liver cirrhosis, the diagnostic AUROC curve of the serum N-glycan RF model

Keywords： Liver fibrosis     Chronic hepatitis B     Serum N-glycan     N-glycan model     Alanine aminotransferase    

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Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches Article

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Engineering 2023, Volume 26, Issue 7,   Pages 132-150 doi: https://doi.org/10.1016/j.eng.2023.02.016

Abstract: To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effectiveThrough the detailed structural analysis of selected, dauntingly complex N-glycans from chickenMoreover, this approach "visualizes" N-glycans that have been difficult to identifyfar—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycanstructures, potentially providing useful new targets for biomarker discovery.

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary    

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Damage assessment of laminated composite beam structures using damage locating vector (DLV) method

VO-DUY,N. NGUYEN-MINH,H. DANG-TRUNG,A. TRAN-VIET,T. NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 457-465 doi: 10.1007/s11709-015-0303-0

Abstract: normalized cumulative energy ( ) is employed to locate multiple damage sites in laminated composite beam structures

Keywords： normalized cumulative energy     structural health monitoring (SHM)     damage locating vector method (DLV)     laminated composite beam structure    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract: Here, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkersThese two N-glycan biomarkers are specific for diagnosing SLE, as no significant changes inNotably, the two N-glycan biomarkers proved to be autoantibody-independent and all-stage patientThe two N-glycan biomarkers are demonstrated to be located on the Fc region based on fragment-specificglycan analysis and glycopeptide analysis, suggesting their close correlation with disease activity.

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Computational Aspects of Dam Risk Analysis: Findings and Challenges

Ignacio Escuder-Bueno,Guido Mazzà,Adrián Morales-Torres,Jesica T.

Engineering 2016, Volume 2, Issue 3,   Pages 319-324 doi: 10.1016/J.ENG.2016.03.005

Abstract:

In recent years, risk analysis techniques have proved to be a useful tool to inform dam safety management. This paper summarizes the outcomes of three themes related to dam risk analysis discussed in the Benchmark Workshops organized by the International Commission on Large Dams Technical Committee on “Computational Aspects of Analysis and Design of Dams.” In the 2011 Benchmark Workshop, estimation of the probability of failure of a gravity dam for the sliding failure mode was discussed. Next, in 2013, the discussion focused on the computational challenges of the estimation of consequences in dam risk analysis. Finally, in 2015, the probability of sliding and overtopping in an embankment was analyzed. These Benchmark Workshops have allowed a complete review of numerical aspects for dam risk analysis, showing that risk analysis methods are a very useful tool to analyze the risk of dam systems, including downstream consequence assessments and the uncertainty of structural models.

Keywords： Dams     Risk analysis     Computational methods     Safety management     Hydraulic structures    

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Application and development of modern long-span space structures in China

Shilin DONG, Yang ZHAO, Dong XING

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 3,   Pages 224-239 doi: 10.1007/s11709-012-0166-6

Abstract: Modern long-span space structures, developed during the 1970s and 1980s, are light and effective structuresThese structures include air-supported membrane structures, cable-membrane structures, cable truss structures, beam string structures, suspen-domes, cable domes, composite structures of cable dome and single-layersteel structures and so forth., modern flexible space structures and modern rigid-flexible combined space structures.

Keywords： modern long-span space structures     rigid space structures     flexible space structures     rigid-flexible combinedspace structures     application and development    

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Practical optimization of deployable and scissor-like structures using a fast GA method

M. SALAR, M. R. GHASEMI, B. DIZANGIAN

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 3,   Pages 557-568 doi: 10.1007/s11709-018-0497-z

Abstract: This paper addresses practical sizing optimization of deployable and scissor-like structures from a newThese structures have been recently highly regarded for beauty, lightweight, determine behavior, properAt this time, there is a few studies done considering practical optimization of these structures.In foldable scissor-like structures, connections have a complex behavior.are not affordable because they need more material than steel structures and cause more environmental

Keywords： optimization     scissor-like structures     deployable structures     genetic algorithm     ABAQUS    

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Effect of / molecular structures on pyrolysis performance and heat sink of decalin isomers

Frontiers of Chemical Science and Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11705-023-2375-z

Abstract: mixtures (denoted as mix-decalin), in order to clarify the effects of the cis-/trans-structuresThis work demonstrates the relationship between the cis/trans structures and the pyrolysis

Keywords： endothermic fuel     decalin     pyrolysis     heat sink     molecular structure    

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Lateral shear performance of sheathed post-and-beam wooden structures with small panels

Frontiers of Structural and Civil Engineering   Pages 1117-1131 doi: 10.1007/s11709-023-0939-0

Abstract: Sheathed post-and-beam wooden structures are distinct from light-wood structures.coefficients were all greater than 2.5, which satisfied the deformation requirements of residential structuresBased on the test and FE analysis results, the shear strength of the post-and-beam wooden structures

Keywords： post-and-beam wooden structures with sheathed walls     low reversed cyclic loading     bearing capacity     stiffness    

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A numerical framework for underground structures in layered ground under inclined P-SV waves using stiffness

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 1,   Pages 10-24 doi: 10.1007/s11709-022-0904-3

Abstract: A numerical framework was proposed for the seismic analysis of underground structures in layered groundNumerical results show that SV-waves are more destructive to underground structures than P-waves, andthe responses of underground structures are significantly affected by the incident angles.

Keywords： underground structures     seismic response     stiffness matrix method     domain reduction method     P-SV waves    

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Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

Frontiers of Structural and Civil Engineering   Pages 1086-1099 doi: 10.1007/s11709-023-0976-8

Abstract: Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

Keywords： RBF     surrogate model     turbine support structures    

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Cutting performance of surgical electrodes by constructing bionic microstriped structures

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0728-9

Abstract: Surgical electrodes rely on thermal effect of high-frequency current and are a widely used medical tool for cutting and coagulating biological tissue. However, tissue adhesion on the electrode surface and thermal injury to adjacent tissue are serious problems in surgery that can affect cutting performance. A bionic microstriped structure mimicking a banana leaf was constructed on the electrode via nanosecond laser surface texturing, followed by silanization treatment, to enhance lyophobicity. The effect of initial, simple grid-textured, and bionic electrodes with different wettabilities on tissue adhesion and thermal injury were investigated using horizontal and vertical cutting modes. Results showed that the bionic electrode with high lyophobicity can effectively reduce tissue adhesion mass and thermal injury depth/area compared with the initial electrode. The formation mechanism of adhered tissue was discussed in terms of morphological features, and the potential mechanism for antiadhesion and heat dissipation of the bionic electrode was revealed. Furthermore, we evaluated the influence of groove depth on tissue adhesion and thermal injury and then verified the antiadhesion stability of the bionic electrode. This study demonstrates a promising approach for improving the cutting performance of surgical electrodes.

Keywords： surgical electrodes     tissue adhesion     thermal injury     bionic structures     cutting performance     medical    

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Mortarless structures based on topological interlocking

Arcady V. DYSKIN, Elena PASTERNAK, Yuri ESTRIN

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 2,   Pages 188-197 doi: 10.1007/s11709-012-0156-8

Abstract: We review the principle of topological interlocking and analyze the properties of the mortarless structuresWe concentrate on structures built of osteomorphic blocks – the blocks possessing specially engineeredcontact surfaces allowing assembling various 2D and 3D structures.These structures are easy to build and can be made demountable.The overall structural integrity of these structures depends on the force imposed by peripheral constraint

Keywords： topological interlocking     fragmented structures     segmented structures     constraint     delamination     bending stiffness    

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Title Author Date Type Operation

Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Journal Article

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis

Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang

Journal Article

Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Journal Article

Damage assessment of laminated composite beam structures using damage locating vector (DLV) method

VO-DUY,N. NGUYEN-MINH,H. DANG-TRUNG,A. TRAN-VIET,T. NGUYEN-THOI

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Computational Aspects of Dam Risk Analysis: Findings and Challenges

Ignacio Escuder-Bueno,Guido Mazzà,Adrián Morales-Torres,Jesica T.

Journal Article

Application and development of modern long-span space structures in China

Shilin DONG, Yang ZHAO, Dong XING

Journal Article

Practical optimization of deployable and scissor-like structures using a fast GA method

M. SALAR, M. R. GHASEMI, B. DIZANGIAN

Journal Article

Effect of / molecular structures on pyrolysis performance and heat sink of decalin isomers

Journal Article

Lateral shear performance of sheathed post-and-beam wooden structures with small panels

Journal Article

A numerical framework for underground structures in layered ground under inclined P-SV waves using stiffness

Journal Article

Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

Journal Article

Cutting performance of surgical electrodes by constructing bionic microstriped structures

Journal Article

Mortarless structures based on topological interlocking

Arcady V. DYSKIN, Elena PASTERNAK, Yuri ESTRIN

Journal Article